讲授课程：放射生物学，放射医学基础，辐射肿瘤学，辐射免疫学
教育经历：
2007/03–2011/02，韩国庆熙大学，生物学系，研究生/博士，导师：KIMSANGHOON
2004/09–2007/02，韩国庆熙大学，生物学系，研究生/硕士，导师：KIMSANGHOON
2000/09–2004/07，延边大学，动物科学系，本科/学士
工作经历：
2014/8–至今，吉林大学，公共卫生学院放射医学系，副教授
2011/3–2014/7，韩国放射医学研究院，博士后研究员，合作导师：LeeKeeHo
研究领域：辐射诱导基因在DNA损伤修复反应中的作用机制研究；肿瘤放疗敏感性标志物的筛选与功能研究；肝癌标志物的筛选与验证研究
科研项目：
1.国家自然科学基金青年基金项目，31600678、p53靶向调控LOX在肿瘤细胞辐射抗性中的作用及分子机制研究、2017/01–2019/12，22.8万元，结题，主持
2.国家自然科学基金面上项目，81872550、NRP1调控细胞分化及放射性肺纤维化机制、2019/01–2022/12，59万元，在研，主要参与人
3.国家自然科学基金面上项目，81870794、脑缺血早期乳酸通过NDRG2促进反应性星形胶质细胞形成的作用及机制研究、2019/01–2022/12，59万元，在研，主要参与人
4.吉林大学白求恩医学科研支持计划青年科研基金项目，miR-196b增强结肠癌放射敏感作用机制研究，2015/10–2017/09，5万元，结题，主持
5.肿瘤特异性辐射反应基因的筛选与机制研究（419080500274），吉林大学引进人才A类科研启动基金 ,2014.10-2017.10， 35万元，结题，负责人
6.韩国国家研究基金会，NRF-2012R1A1A2008457，
Developmentofnovelanticancertherapyusingmicroorganismswithradiation，2013/01–2017/12，约合人民币57万，结题，参加
7.韩国国家研究基金会，NRF-2012M3A9B6055346，
Omics-basedidentificationandmolecularevaluationofcancer-obesitycoregulatorsduringtheprogressionofobesity-inducedhumanhepatocellularcarcinoma，2013/01–2017/12，约合人民币110万，结题，参加
8.韩国国家研究基金会，0078611，
DevelopmentforanewtherapyofgastrointestinalcancerthroughthefunctionalcontrolofmicroRNAsinducedbyradiation，2009/01–2011/12，约合人民币28万，结题，参加
9.韩国国家研究基金会，0017418，Functionalstudyoftheadaptiveresponseinducedbylowdoseradiation，2007/01–2011/12年，约合人民币40万，结题，参加
学术论文：
◆ Liu CH, Huang ZH, Dong XY, Zhang XQ, Li YH, Zhao G, Sun BS, Shen YN. Inhibition of Uncoupling Protein 2 Enhances the Radiosensitivity of Cervical Cancer Cells by Promoting the Production of Reactive Oxygen Species. Oxid Med Cell Longev. 2020 Mar 4;2020:5135893.
◆ 刘翠花, 董新宇, 李远航, 张新强, 王志成, 赵刚, 申延男。电解耦联蛋白2对Siha细胞辐射敏感性的影响。中华放射医学与防护杂志, 2020, 40(2):88-93.
◆ Wei W, Dong Z, Gao H, Zhang YY, Shao LH, Jin LL, Lv YH, Zhao G, Shen YN, JinSZ. MicroRNA-9 enhanced radiosensitivity and its mechanism of DNA methylation in non-small cell lung cancer. Gene. 2019 Aug 20;710:178-185.
◆ Dong Z, Zhang H, Gong X, Wei W, Lv Y, Chen Z, Wang R, Yi J, Shen Y, Jin S. TheRole of the Tumor Microenvironment in Neuropilin 1-Induced Radiation Resistance in Lung Cancer Cells. J Cancer. 2019 Jul 8;10(17):4017-4030.
◆ Wei W, Zhang HY, Gong XK, Dong Z, Chen ZY, Wang R, Yi JX, Shen YN, Jin SZ. Mechanism of MEN1 Gene in Radiation-Induced Pulmonary Fibrosis in Mice. Gene. 2018 Dec15;678:252-260.
◆ Shen YN, Bae IS, Park GH, Choi HS, Lee KH, Kim SH. MicroRNA-196b enhances the radiosensitivity of SNU-638 gastric cancer cells by targeting RAD23B. Biomed Pharmacother. 2018 Sep;105:362-369.
◆ Meng C, Liu Y, Shen Y, Liu S, Wang Z, Ye Q, Liu H, Liu X, Jia L. MicroRNA-26b suppresses autophagy in breast cancer cells by targeting DRAM1 mRNA, and is downregulated by irradiation. ONCOLOGY LETTERS，2018，15: 1435-1440.
◆ Lee JS, Kim MY, Park ER, Shen YN, Jeon JY, Cho EH, Park SH, Han CJ, Choi DW,Jang JJ, Suh KS, Hong J, Kim SB, Lee KH. TMEM165, a Golgi Transmembrane Protein, Is a Novel Marker for Hepatocellular Carcinoma and Its Depletion Impairs Invasion Activity. Oncol Rep. 2018 Sep;40(3):1297-1306.
◆ Jeon JY, Lee JS, Park ER, Shen YN, Kim MY, Shin HJ, Joo HY, Cho EH, Moon SM,Shin US, Park SH, Han CJ, Choi DW, Gu MB, Kim SB, Lee KH. Protein Arginine Methyltransferase 5 Is Implicated in the Aggressiveness of Human Hepatocellular Carcinoma and Controls the Invasive Activity of Cancer Cells. Oncol Rep. 2018 Jul;40(1):536-544.
◆ 李鑫, 马云飞, 唐庚, 韦麒, 纪红池，田嘉安，申延男，王志成。线粒体靶向KillerRed诱导的ROS增强辐射对Hela细胞的增值抑制作用。吉林大学学报（医学版）, 2018, 44(4):718-723.
◆ Ye Q, Meng C, Shen Y, Ji J, Wang X, Zhou S, Jia L, Wang Y. Caveolin-1 Mediates Low-Intensity Ultrasound-Induced Apoptosis via Downregulation of Signal Transducer and Activator of Transcription 3 Phosphorylation in Laryngeal Carcinoma Cells. Ultrasound Med Biol. 2016 Sep;42(9):2253-60.
◆ 魏威，陈海燕，邵立虹，史涛，高辉，董卓，金霖霖，赵刚，申延男，金顺子。电离辐射对小鼠胸腺Th17细胞相关细胞因子的影响。中华放射医学与防护杂志, 2015, 35(10):185-187.
◆ Kim SH, Park ER, Joo HY, Shen YN, Hong SH, Kim CH, Singh R, Lee KH, Shin HJ. RRM1 maintains centrosomal integrity via CHK1 and CDK1 signaling during replication stress. Cancer Lett. 2014 Jan 14. pii: S0304-3835(14)00014-7.
◆ Shen YN, Shin HJ, Joo HY, Park ER, Kim SH, Hwang SG, Park SJ, Kim CH, Lee KH. Inhibition of HAS2 induction enhances the radiosensitivity of cancer cells via persistent DNA damage. Biochem Biophys Res Commun. 2014 Jan 17;443(3):796-801.
◆ Woo SR, Byun JG, Kim YH, Park ER, Joo HY, Yun M, Shin HJ, Kim SH, Shen YN, Park JE, Park GH, Lee KH. SIRT1 suppresses cellular accumulation of β-TrCP E3 ligase via protein degradation. Biochem Biophys Res Commun. 2013 Nov 29;441(4):831-7.
◆ Joo HY, Woo SR, Shen YN, Yun MY, Shin HJ, Park ER, Kim SH, Park JE, Ju YJ, Hong SH, Hwang SG, Cho MH, Kim J, Lee KH. SIRT1 interacts with and protects glyceraldehyde-3-phosphate dehydrogenase (GAPDH) from nuclear translocation: Implications for cell survival after irradiation. Biochem Biophys Res Commun. 2012 Aug 10;424(4):681-6.
◆ YN Shen, SH. Kim, DH Yoon, HG Lee, HS Kang, KS Seo. Proteome Analysis of Bovine longissimus dorsi Muscle Associated with the Marbling Score. Asian-Aust. J. Anim. Sci. 2012. 25(8):1083-1088.
◆ Choi SY, Shen YN, Woo SR, Yun M, Park JE, Ju YJ, Jeong J, Shin HJ, Joo HY, Park ER, Lee JK, Kim SH, Cho MH, Kong IS, Lee KH. Mitomycin C and doxorubicin elicit conflicting signals by causing accumulation of cyclin E prior to p21WAF1/CIP1 elevation in human hepatocellular carcinoma cells. Int J Oncol. 2012 Jan;40(1):277-86. (co-first author)
◆ Zhang Q, Lee HG, Han JA, Kim EB, Kang SK, Yin J, Baik M, Shen Y, Kim SH, Seo KS, Choi YJ. Differentially expressed proteins during fat accumulation in bovine skeletal muscle. Meat Sci. 2010 Nov;86(3):814-20.
◆ Shen YN, Kim YM, Yun CH, Moon YS, Kim SH. Transcriptional activation of pref-1 by E2F1 in 3T3 L1 cells. BMB Rep. 2009 Oct 31;42(10):691-6.
◆ Kim NS, Shen YN, Kim TY, Byun SJ, Jeon IS, Kim SH. Expression of AGR-2 in chicken oviduct during laying period. J Biochem Mol Biol. 2007 Mar 31;40(2):212-7.
◆ KS Seo, YN Shen, AJ Salces, DH Yoon, HG Lee, SH. Kim. Correlation Analysis between the Breeding Value of Carcass Traits in Hanwoo (Korean Brown Cattle), Bos Taurus, L. and Spot Intensity on Two-dimensional Gel Electrophoresis. Asian-Aust. J. Anim. Sci. 2006. 19(10):1404-1408.
获奖情况：
2006年度 韩国庆熙大学 优秀留学生论文奖
2007-2009年 韩国庆熙大学 理工类奖学金获得者
2016年度吉林大学白求恩医学部2016年白求恩十佳班主任
学术兼职：
中国研究型医院学会肿瘤放射生物与多模态诊疗专业委员会委员、中国核学会核应急医学分会理事、中华预防医学会放射卫生专业委员会青年委员、中国生物物理学会辐射与环境专业委员会青年委员、中华预防医学会放射卫生专业委员会青年委员、吉林省肿瘤放疗青年委员会委员、吉林省核学会理事、吉林省出版产品质量检测专家
